This paper presents the methodology for optimising blasting and comminution processes in terms of fragmentation developed by Metso Minerals Process Technology Asia-Pacific and South America (MMPT). The methodology is called process integration and optimisation (PIO) and involves a number of steps: benchmarking, rock characterisation, measurements, modelling/simulation of blasting and comminution processes and where required, material tracking. The measurements collected while at site are combined with rock characterisation and definition of ore domains to model the complete process chain. These data are used to develop site-specific models of blast fragmentation, crushing, grinding and flotation. This allows customised blast patterns to be developed that optimise both crushing and grinding performance. For each domain, blast designs are recommended to generate the optimal fragmentation size for downstream processes. The objective is to minimise the overall cost for the entire process and the changes often have a positive impact on the mining operation. Process constraints such as wall stability, ore dilution, muck pile characteristics, size of mining equipment, size and installed power of crushing and milling equipment and other process bottlenecks are considered in the blast designs. This methodology has allowed many operations around the world to significantly increase their production: generating typically five to 20 per cent higher concentrator throughput. A number of case studies will be discussed in this paper to describe the structured approach taken and demonstrate the benefits that are achievable. This paper will focus on the role of blasting in the optimisation of the entire mine to mill process chain and discuss elements of the PIO methodology: rock characterisation, fragmentation modelling and measurement, the relationship between fragmentation and mill throughput and material tracking.