The skin redoxome

被引：11
|
作者：
Schalka, S. [1 ]
Silva, M. S. [1 ]
Lopes, L. F. [2 ]
de Freitas, L. M. [2 ]
Baptista, M. S. [2 ]
机构：
[1] Med Skin Res Ctr, Osasco, Brazil
[2] Univ Sao Paulo, Inst Chem, Dept Biochem, Sao Paulo, Brazil
来源：
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY | 2022年 / 36卷 / 02期
基金：
巴西圣保罗研究基金会;
关键词：
NF-KAPPA-B; OXIDATIVE STRESS; REACTIVE OXYGEN; IN-VIVO; VISIBLE-LIGHT; CARBONYLATED PROTEINS; BARRIER FUNCTION; BLUE-LIGHT; VITAMIN-E; ANTIOXIDANTS;
D O I：
10.1111/jdv.17780
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Redoxome is the network of redox reactions and redox active species (ReAS) that affect the homeostasis of cells and tissues. Due to the intense and constant interaction with external agents, the human skin has a robust redox signalling framework with specific pathways and magnitudes. The establishment of the skin redoxome concept is key to expanding knowledge of skin disorders and establishing better strategies for their prevention and treatment. This review starts with its definition and progress to propose how the master redox regulators are maintained and activated in the different conditions experienced by the skin and how the lack of redox regulation is involved in the accumulation of several oxidation end products that are correlated with various skin disorders.
引用
收藏
页码：181 / 195
页数：15
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