Electroreductive synthesis of polyfunctionalized pyridin-2-ones from acetoacetanilides and carbon disulfide with oxygen evolution

被引：13

作者：

Xu, Lichun ^{[1
]}

Ma, Zhongxiao ^{[1
]}

Hu, Xi ^{[1
]}

Zhang, Xin ^{[1
]}

Gao, Shulin ^{[1
]}

Liang, Deqiang ^{[1
]}

Wang, Baoling ^{[1
]}

Li, Weili ^{[1
]}

Li, Yanni ^{[1
]}

机构：

[1] Kunming Univ, Sch Chem & Chem Engn, Kunming 650214, Yunnan, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 05期

基金：

中国国家自然科学基金;

关键词：

C-H FUNCTIONALIZATION; N-ALLYL ANILINES; METAL-FREE; ALKENES; ELECTROCHEMISTRY; 2-PYRIDONES; CYCLIZATION; CLEAVAGE; PHENOLS; ACCESS;

D O I：

10.1039/d1ob02379a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A chemical reductant or a sacrificial electron donor is required in any reduction reactions, generally resulting in undesired chemical waste. Herein, we report a reductant-free reductive [3 + 2 + 1] annulation of beta-keto amides with CS2 enabled by the synergy of electro/copper/base using water as an innocuous anodic sacrifice with O-2 as a sustainable by-product. This electrochemical protocol is mild and provides access to polyfunctionalized pyridin-2-ones from simple starting materials in a single step.

引用

页码：1013 / 1018

页数：6

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