Cytomechanics of cadherin-mediated cell-cell adhesion

被引：229
|
作者：
Adams, CL
Nelson, WJ
机构：
[1] Cytokinet Inc, San Francisco, CA 94040 USA
[2] Stanford Univ, Sch Med, Beckman Ctr, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 05期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0955-0674(98)80031-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cadherin-mediated adhesion regulates transitions from initial cell-cell recognition to loosely adherent cell clusters and ultimately, to strongly compacted groups of cells in colonies. Recent studies have described distinct roles for intermolecular clustering of cadherins as well as interactions of cadherin with the actin cytoskeleton in establishing cell-cell adhesion. Integrating cytomechanical roles of cadherin-mediated adhesion will lead to a greater understanding of how cadherins regulate tissue morphogenesis.
引用
收藏
页码：572 / 577
页数：6
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