Identification and PEP Inhibitory Activity of Acetophenone Glucosides from the Clove Buds (Syzygium aromaticum)

被引：16

作者：

Han, Ah-Reum

Paik, Young-Sook ^{[1
]}

机构：

[1] Kyung Hee Univ, Dept Appl Chem, Yongin 446701, South Korea

来源：

JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY | 2010年 / 53卷 / 06期

关键词：

acetophenone glucoside; prolyl endopeptidase inhibitor; Syzygium aromaticum; ENDOPEPTIDASE; LEAVES; CHROMONES; PERRY;

D O I：

10.3839/jksabc.2010.129

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Two new acetophenone glucosides, 2,6-dihydroxy-4-methoxyacetophenone 3-C-beta-D-glucoside (1) and 2,6-dihydroxy-4-methoxyacetophenone 3-C-beta-D-(6'-O-galloyl)glucoside (2), together with three known compounds, eugenin (3), 8-C-glucosylnoreugenin (4), and gallic acid (5) were isolated from the EtOAc soluble fraction of the MeOH extract of clove buds (Syzygium aromaticum). Of these, compound 2 showed significant prolyl endopeptidase inhibitory activity with IC(50) value of 17.2+/-1.1 mu M, suggesting it may have potential use against memory impairment and cognitive decline.

引用

页码：847 / 851

页数：5

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