Identification and PEP Inhibitory Activity of Acetophenone Glucosides from the Clove Buds (Syzygium aromaticum)

被引：16
|
作者：
Han, Ah-Reum
Paik, Young-Sook [1 ]
机构：
[1] Kyung Hee Univ, Dept Appl Chem, Yongin 446701, South Korea
来源：
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY | 2010年 / 53卷 / 06期
关键词：
acetophenone glucoside; prolyl endopeptidase inhibitor; Syzygium aromaticum; ENDOPEPTIDASE; LEAVES; CHROMONES; PERRY;
D O I：
10.3839/jksabc.2010.129
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Two new acetophenone glucosides, 2,6-dihydroxy-4-methoxyacetophenone 3-C-beta-D-glucoside (1) and 2,6-dihydroxy-4-methoxyacetophenone 3-C-beta-D-(6'-O-galloyl)glucoside (2), together with three known compounds, eugenin (3), 8-C-glucosylnoreugenin (4), and gallic acid (5) were isolated from the EtOAc soluble fraction of the MeOH extract of clove buds (Syzygium aromaticum). Of these, compound 2 showed significant prolyl endopeptidase inhibitory activity with IC(50) value of 17.2+/-1.1 mu M, suggesting it may have potential use against memory impairment and cognitive decline.
引用
收藏
页码：847 / 851
页数：5
相关论文
共 50 条
  • [1] Identification and PEP inhibitory activity of acetophenone glucosides from the clove buds (Syzygium aromaticum)
    Ah-Reum Han
    Young-Sook Paik
    Journal of the Korean Society for Applied Biological Chemistry, 2010, 53 : 847 - 851
  • [2] In vitro Antibacterial and Antifungal Activity of Flower Buds (Clove) of Syzygium aromaticum
    Begum, Sabira
    Sara
    Tauseef, Saima
    Siddiqui, Bina Shaheen
    Nizami, Shaikh Sirajuddin
    Ghulam, Hina
    Ahmad, Aqeel
    JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, 2014, 36 (04): : 723 - 727
  • [3] New Flavonol Glucuronides from the Flower Buds of Syzygium aromaticum (Clove)
    Ryu, Byeol
    Kim, Hye Mi
    Lee, Jin Su
    Lee, Chan Kyu
    Sezirahiga, Jurdas
    Woo, Jeong-Hwa
    Choi, Jung-Hye
    Jang, Dae Sik
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2016, 64 (15) : 3048 - 3053
  • [4] A new acetophenone glycoside from the flower buds of Syzygium aromaticum (cloves)
    Ryu, Byeol
    Kim, Hye Mi
    Woo, Jeong-Hwa
    Choi, Jung-Hye
    Jang, Dae Sik
    FITOTERAPIA, 2016, 115 : 46 - 51
  • [5] Antimutagenic activity of phenylpropanoids from clove (Syzygium aromaticum)
    Miyazawa, M
    Hisama, M
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2003, 51 (22) : 6413 - 6422
  • [6] Inhibitory components from the buds of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells
    Arung, Enos Tangke
    Matsubara, Eri
    Kusuma, Irawan Wijaya
    Sukaton, Edi
    Shimizu, Kuniyoshi
    Kondo, Ryuichiro
    FITOTERAPIA, 2011, 82 (02) : 198 - 202
  • [7] Identification of Nonvolatile Compounds in Clove (Syzygium aromaticum) from Manado
    Fathoni, A.
    Saepudin, E.
    Cahyana, A. H.
    Rahayu, D. U. C.
    Haib, J.
    INTERNATIONAL SYMPOSIUM ON CURRENT PROGRESS IN MATHEMATICS AND SCIENCES 2016 (ISCPMS 2016), 2017, 1862
  • [8] CRATAEGOLIC ACID AND STEROID GLUCOSIDES FROM FLOWERING BUDS OF SYZYGIUM-AROMATICUM
    BRIESKORN, CH
    MUNZHUBER, K
    UNGER, G
    PHYTOCHEMISTRY, 1975, 14 (10) : 2308 - 2309
  • [9] Biological Activity of Aromatic Compounds from Clove (Syzygium aromaticum)
    Surbhi
    Sushma
    Sharma, Reena
    JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL, 2021, 33 (57A) : 318 - 322
  • [10] Antinociceptive Activity of Syzygium Aromaticum Linn. Flower Buds (Clove) Extract and its Fractions
    Sara
    Begum, Sabira
    Malhi, Saima Mahmood
    Simjee, Shabana U.
    Siddiqui, Bina S.
    JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, 2022, 44 (03): : 263 - 269
12345