Aperture Size Influences Oxidation in Positive-Ion Nitrogen Direct Analysis in Real Time Mass Spectrometry

被引:4
|
作者
Cody, Robert B. [1 ]
机构
[1] JEOL USA Inc, Peabody, MA 01960 USA
关键词
AMBIENT IONIZATION; NITRIC-OXIDE; ARGON; CHROMATOGRAPHY;
D O I
10.1021/jasms.2c00115
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Direct Analysis in Real Time (DART) mass spectrometry commonly uses helium as the DART gas. With the looming helium shortage, other gases are being evaluated for DART. Nitrogen is inexpensive and readily available, making it a desirable alternative. However, NO+ reagent ions present in positive-ion nitrogen DART result in extensive oxidation for many compounds. The DART source uses a ceramic insulator cap to protect the operator from electrical shock. The most common cap has an aperture with a 2.5 mm inner diameter, through which the gas exits the DART source. By using a cap with a narrow (0.5 mm) ID, oxidation can be significantly reduced for nitrogen DART. The 0.5 mm cap is hypothesized to reduce back-diffusion of atmospheric oxygen into the DART source, with a reduction in the relative abundance of NO and increase in the relative abundance of [(H2O)(2) + H](+) as the reactive species responsible for ionization of the analytes.
引用
收藏
页码:1329 / 1334
页数:6
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