A case of Degos disease: demonstration of C5b-9-mediated vascular injury

被引：9

作者：

Umemura, Masayu ^{[1
]}

Miwa, Yusuke ^{[1
]}

Yanai, Ryo ^{[1
]}

Isojima, Sakiko ^{[1
]}

Tokunaga, Takahiro ^{[1
]}

Tsukamoto, Hiroyuki ^{[1
]}

Takahashi, Ryo ^{[1
]}

Yajima, Nobuyuki ^{[1
]}

Kasama, Tsuyoshi ^{[1
]}

Takahashi, Nanako ^{[2
]}

Sueki, Hirohiko ^{[2
]}

Yamaguchi, Sayaka ^{[3
]}

Arai, Katsuhito ^{[3
]}

Takeuchi, Yoshiaki ^{[3
]}

Ohike, Nobuyuki ^{[4
]}

Norose, Tomoko ^{[4
]}

Yamochi-Onizuka, Toshiko ^{[4
]}

Takimoto, Masafumi ^{[4
]}

机构：

[1] Showa Univ, Sch Med, Div Rheumatol, Dept Med, Tokyo 142, Japan

[2] Showa Univ, Sch Med, Dept Dermatol, Tokyo 142, Japan

[3] Showa Univ, Sch Med, Dept Med, Div Gastroenterol, Tokyo 142, Japan

[4] Showa Univ, Sch Med, Dept Pathol, Tokyo 142, Japan

来源：

MODERN RHEUMATOLOGY | 2015年 / 25卷 / 03期

关键词：

Degos disease; C5b-9; deposition; MALIGNANT ATROPHIC PAPULOSIS;

D O I：

10.3109/14397595.2013.874761

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 68-year-old Japanese male presented with atrophic erythematous white lesions with peripheral dark reddish rims on his back. Multiple ulcers were detected from his stomach to his large intestine using endoscopy. Although the patient was given high doses of a steroid, aspirin, dipyridamole, and intravenous immunoglobulin therapy, he died of gastro intestinal hemorrhage, perforation and septic shock. An autopsy examination revealed pauci-inflammatory thrombotic microangiopathy with endothelial cell injury, fibrous occlusive arteriopathy, and vascular C5b-9 deposition in the wall of the gastro intestinal tract from the esophagus to the large intestine as well as in the dermis of the skin.

引用

页码：480 / 483

页数：4

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