Base Pair Openings and Temperature Dependence of DNA Flexibility

被引：26
|
作者：
Theodorakopoulos, Nikos [1 ,2 ,3 ]
Peyrard, Michel [3 ]
机构：
[1] Natl Hellen Res Fdn, Inst Theoret & Phys Chem, GR-11635 Athens, Greece
[2] Univ Konstanz, Fachbereich Phys, D-78457 Constance, Germany
[3] Ecole Normale Super Lyon, Lab Phys CNRS, F-69364 Lyon 7, France
来源：
PHYSICAL REVIEW LETTERS | 2012年 / 108卷 / 07期
关键词：
PERSISTENCE LENGTH; MOLECULAR-WEIGHT; IMINO PROTON; DOUBLE HELIX; DENATURATION; EXCHANGE; BIREFRINGENCE; CYCLIZATION; FRAGMENTS; ACIDS;
D O I：
10.1103/PhysRevLett.108.078104
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
The relationship of base pair openings to DNA flexibility is examined. Published experimental data on the temperature dependence of the persistence length by two different groups are well described in terms of an inhomogeneous Kratky-Porot model with soft and hard joints, corresponding to open and closed base pairs, and sequence-dependent statistical information about the state of each pair provided by a Peyrard-Bishop-Dauxois (PBD) model calculation with no freely adjustable parameters.
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页数：4
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