Copper Catalyzed Cross-Coupling of Iodobenzoates with Bromozinc-difluorophosphonate

被引：142
|
作者：
Feng, Zhang [1 ]
Chen, Fei [1 ]
Zhang, Xingang [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 07期
关键词：
ELECTRON-DEFICIENT POLYFLUOROARENES; ARYL IODIDES; BENZYLIC PHOSPHONATES; FACILE SYNTHESIS; FLUORINE; DIFLUOROMETHYLATION; ANALOGS; REAGENT; ZINC; TRIFLUOROMETHYLATION;
D O I：
10.1021/ol3006425
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper-catalyzed cross-coupling of iodobenzoates with bromozinc-difluorophosphonate, generated from diethyl bromodifluoromethylphosphonate and zinc in dioxane, is reported. The notable features of this reaction are its high reaction efficiency, excellent functional group compatibility, and operational simplicity. This protocol provides a useful and facile access to aryldifluorophosphonates of interest in life science.
引用
收藏
页码：1938 / 1941
页数：4
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