Synthesis and properties of novel oligodeoxynucleotides containing 6,3′-methanodeoxyuridine

被引:0
|
作者
Moriguchi, Tomohisa [1 ]
Yaniato, Fumisada [1 ]
Shinozuka, Kazuo [1 ]
机构
[1] Gunma Univ, Grad Sch Engn, Kiryu, Gunma 3768615, Japan
关键词
D O I
10.1246/cl.2008.548
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
This paper deals with the synthesis and properties of novel oligodeoxynucleotide containing 6,3'-methanodeoxyuridine which is connected between C-6 of pyrimidine base and C-3' of deoxyribose by a methylene group. The modified base was successfully introduced into the oligodeoxynucleotide by the standard method. The modified oligodeoxynucleotide formed the less stable duplex with both complementary DNA and RNA. The CD spectra indicated that the duplex formed the noncanonical duplex structure distinct from the A-form or B-form structure.
引用
收藏
页码:548 / 549
页数:2
相关论文
共 50 条
  • [31] ANTISENSE OLIGODEOXYNUCLEOTIDES - SYNTHESIS, BIOPHYSICAL AND BIOLOGICAL EVALUATION OF OLIGODEOXYNUCLEOTIDES CONTAINING MODIFIED PYRIMIDINES
    SANGHVI, YS
    HOKE, GD
    FREIER, SM
    ZOUNES, MC
    GONZALEZ, C
    CUMMINS, L
    SASMOR, H
    COOK, PD
    NUCLEIC ACIDS RESEARCH, 1993, 21 (14) : 3197 - 3203
  • [32] Enhancement of transport properties introduced complex defect in (6,3) carbon nanotubes
    Cheng, Cai-Ping
    Hu, Hui-Fang
    Zhang, Zhao-Jin
    Wang, Xiaowei
    Chen, Ying
    Liu, Quanhui
    Peng, Ping
    MODERN PHYSICS LETTERS B, 2015, 29 (09):
  • [33] Anxioselective properties of 6,3'-dinitroflavone, a high affinity benzodiazepine receptor ligand
    Wolfman, C
    Viola, H
    Marder, M
    Wasowski, C
    Ardenghi, P
    Izquierdo, I
    Paladini, AC
    Medina, JH
    JOURNAL OF NEUROCHEMISTRY, 1997, 69 : S248 - S248
  • [34] 6,3′-dibromoflavone and 6-nitro-3′-bromoflavone:: New additions to the 6,3′-disubstituted flavone family of high-affinity ligands of the brain benzodiazepine binding site with agonistic properties
    Viola, H
    Marder, M
    Wasowski, C
    Giorgi, O
    Paladini, AC
    Medina, JH
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 273 (02) : 694 - 698
  • [35] Synthesis and properties of novel polyimides containing 2, 6-benzobisoxazole units
    Meng, Xiang-Li
    Huang, Yu-Dong
    Lv, Zu-Shun
    Zhou, Yi-Wen
    Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering, 2010, 26 (05): : 136 - 139
  • [36] PMST 6,3 ECCENTRIC TABLE PRESS
    不详
    MECHANIK MIESIECZNIK NAUKOWO-TECHNICZNY, 1974, 47 (02): : 103 - 104
  • [37] Synthesis and evaluation of oligodeoxynucleotides containing 3'-C-aminomethyl- and 3'-C-methylthymidine
    Wang, GY
    Middleton, PJ
    He, LY
    Stoisavljevic, V
    Seifert, WE
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 1997, 16 (04): : 445 - 454
  • [38] COPRIME COORDINATES IN REGULAR TESSELATION [6,3]
    ALTGELD, JP
    AMERICAN MATHEMATICAL MONTHLY, 1966, 73 (02): : 209 - &
  • [39] A POSTOLIGOMERIZATION SYNTHESIS OF OLIGODEOXYNUCLEOTIDES CONTAINING POLYCYCLIC AROMATIC HYDROCARBON ADDUCTS AT THE N(6) POSITION OF DEOXYADENOSINE
    KIM, SJ
    STONE, MP
    HARRIS, CM
    HARRIS, TM
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (13) : 5480 - 5481
  • [40] Synthesis and Crystal Structure of a New (6,3)-Connected Ni(II) Coordination Polymer
    Wang Ai-Dong
    Qiu Jian-Chao
    Guo Feng
    Zhang Xiu-Ling
    CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2010, 29 (06) : 982 - 985