Synthesis and properties of novel oligodeoxynucleotides containing 6,3′-methanodeoxyuridine

被引：0
|
作者：
Moriguchi, Tomohisa [1 ]
Yaniato, Fumisada [1 ]
Shinozuka, Kazuo [1 ]
机构：
[1] Gunma Univ, Grad Sch Engn, Kiryu, Gunma 3768615, Japan
来源：
CHEMISTRY LETTERS | 2008年 / 37卷 / 05期
关键词：
D O I：
10.1246/cl.2008.548
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This paper deals with the synthesis and properties of novel oligodeoxynucleotide containing 6,3'-methanodeoxyuridine which is connected between C-6 of pyrimidine base and C-3' of deoxyribose by a methylene group. The modified base was successfully introduced into the oligodeoxynucleotide by the standard method. The modified oligodeoxynucleotide formed the less stable duplex with both complementary DNA and RNA. The CD spectra indicated that the duplex formed the noncanonical duplex structure distinct from the A-form or B-form structure.
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页码：548 / 549
页数：2
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