Practical synthesis of DQ-113, a new quinolone antibacterial agent, by using the intramolecular Horner-Wadsworth-Emmons reaction

被引：7

作者：

Inagaki, H ^{[1
]}

Takeda, T ^{[1
]}

Miyauchi, RN ^{[1
]}

Kawakami, K ^{[1
]}

Takahashi, H ^{[1
]}

Takemura, M ^{[1
]}

机构：

[1] Daiichi Pharmaceut Co Ltd, Med Chem Res Lab, Edogawa Ku, Tokyo 1348630, Japan

来源：

HETEROCYCLES | 2004年 / 63卷 / 03期

关键词：

D O I：

10.3987/COM-03-9972

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical route was developed for synthesizing the C-7 substituent of DQ-113 (6, 5-amino-7-[(3S,4R)-4-(1-aminocycloprop-l-yl)-3-fluoro-pyrrolidin-l-yl]-6-fluoro-l-[(IR,2S)-2-fluorocyclopropan-l-yl]-1,4-dihydro- 8-methyl-4-oxoquinolin-3-carboxylic acid), a new quinolone antibacterial agent for serious infections caused by Gram-positive pathogens. The key step was the intramolecular Homer-Wadsworth-Emmons reaction. In addition, the yield of the final aromatic micleophilic substitution reaction was improved.

引用

页码：699 / 706

页数：8

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