In Vivo Imaging of the Cannabinoid CB1 Receptor With Positron Emission Tomography

被引：11
|
作者：
Hirvonen, J. [1 ,2 ]
机构：
[1] Turku Univ Hosp, Dept Radiol, FIN-20520 Turku, Finland
[2] Univ Turku, Turku PET Ctr, Turku, Finland
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2015年 / 97卷 / 06期
关键词：
D O I：
10.1002/cpt.116
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Positron emission tomography (PET) can visualize and quantify receptors and other targets in the living human brain, and recent progress in radioligand development has enabled measurement of cannabinoid type-1 (CB1) receptors. Cannabinoid CB1 receptors have been implicated in multiple human diseases, such as obesity, mood disorders, and addiction. First in vivo human studies have shown distinctive spatial and temporal alterations in cannabinoid CB1 receptor binding in addictive disorders.
引用
收藏
页码：565 / 567
页数：3
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