Kinetic Resolution of β-Lactams via Enantioselective N-Acylation

被引：31
|
作者：
Yang, Xing [1 ]
Bumbu, Valentina D. [1 ]
Birman, Vladimir B. [1 ]
机构：
[1] Washington Univ, Dept Chem, St Louis, MO 63130 USA
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 18期
基金：
美国国家科学基金会;
关键词：
ACYL TRANSFER; NONENZYMATIC ACYLATION; AMINO-ACIDS; BINDING APPROACH; ALCOHOLS; CATALYST; BENZOTETRAMISOLE; DERIVATIVES;
D O I：
10.1021/ol201911z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Enantioselective N-acylation of 4-aryl-beta-lactams in the presence of acyl transfer catalyst CI-PIQ provides an effective method for their nonenzymatic kinetic resolution.
引用
收藏
页码：4755 / 4757
页数：3
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