Syntheses of oxazabicycle library via one-pot tandem reactions

被引：14
|
作者：
Lai, Jiun-Ting
Shieh, Pei-Shan
Huang, Wei-Hao
Yang, Ding-Yah [1 ]
机构：
[1] Tunghai Univ, Dept Chem, Taichung 407, Taiwan
来源：
JOURNAL OF COMBINATORIAL CHEMISTRY | 2008年 / 10卷 / 03期
关键词：
D O I：
10.1021/cc8000025
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A practical protocol for the preparation of a parallel solution-phase library of oxazabicycle is reported. Target compounds were obtained in moderate to good yields by a Yb(OTf)(3)-catalyzed one-pot tandem reaction from various anisidines, aromatic aldehydes, isobutyraldehyde, and 4-hydroxycoumarins/dimedone. Purification of the final products by either recrystallization in ethyl acetate/methylene chloride or column chromatography allowed easy isolation of the 18 components of the array.
引用
收藏
页码：381 / 386
页数：6
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