Four new chamigrane sesquiterpenoids from the opistobranch mollusk Aplysia dactylomela

被引：12
|
作者：
Shubina, L. K. [1 ]
Fedorov, S. N. [1 ]
Kalinovskiy, A. I. [1 ]
Dmitrenok, A. S. [1 ]
Jin, J. O. [2 ]
Song, M. G. [2 ]
Kwak, J. Y. [2 ]
Stonik, V. A. [1 ]
机构：
[1] Russian Acad Sci, Pacific Inst Bioorgan Chem, Far Eastern Branch, Vladivostok 690022, Russia
[2] Dong A Univ, Med Res Ctr Canc Mol Therapy, Pusan 602714, South Korea
来源：
RUSSIAN CHEMICAL BULLETIN | 2007年 / 56卷 / 10期
基金：
俄罗斯基础研究基金会;
关键词：
mollusks; sesquiterpenoids; spiro compounds; organobromine compounds; anticancer activity;
D O I：
10.1007/s11172-007-0329-0
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Four new chamigrane sesquiterpenoids, (6S,10S)-10-bromo-3,11,11-trimethyl-7-methylidenespiro[5.5]undec-2-ene-4-one, (4S,6S,10S)-10-bromo-3,11,11-trimethyl-7-methylidenespiro[5.5]undec-2-ene-4-ol, (3R,4S,6S,10R)-10-bromo-3,11,11-trimethyl-7-methylidenespiro[5.5]undecane-3,4-diol, and (6S,7S,11R)-2-chloro-3,7,11-trimethyl-10-methylidenespiro[5.5]undec-2-ene-7-ol, were isolated from the sea hare Aplysia dactylomela. The chemical structures of new compounds were established by NMR spectroscopy and mass spectrometry. The cytotoxic activity of some of the obtained compounds against promyelocytic HL-60 and monocytic THP-1 leukemia cells was demonstrated.
引用
收藏
页码：2109 / 2114
页数：6
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