Diuretics and tubuloglomerular feedback.

被引：0

作者：

Knauf, H ^{[1
]}

Greger, R ^{[1
]}

Mutschler, E ^{[1
]}

Paliege, R ^{[1
]}

Thurau, K ^{[1
]}

机构：

[1] ST BERNWARD KRANKENHAUS,MED KLIN 1,HILDESHEIM,GERMANY

来源：

NIEREN-UND HOCHDRUCKKRANKHEITEN | 1996年 / 25卷 / 04期

关键词：

tubuloglomerular feedback; loop diuretics; thiazides; antikaliuretics; renal hemodynamics;

D O I：

暂无

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The GFR is depressed by 40 to 50% once the natriuresis induced by thiazides exceeds 35 mmol/h. This effect is termed tubuloglomerular feedback (TGR). Loop diuretics do not affect the GFR and the RPF as they block the TGR. Therefore their effect is not limited by the reduction of GFR. Hence thiazides being self-limited were earlier called low ceiling diuretics and loop diuretics were called ''high ceiling'' diuretics.

引用

页码：147 / 153

页数：7

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