P66Shc, oxidative stress and aging - Importing a lifespan determinant into mitochondria

被引：70

作者：

Pinton, Paolo ^{[1
,2
,3
]}

Rizzuto, Rosario ^{[1
,2
,3
]}

机构：

[1] Univ Ferrara, Sect Gen Pathol, Dept Expt & Diagnost Med, I-44100 Ferrara, Italy

[2] Univ Ferrara, ER GenTech Lab, I-44100 Ferrara, Italy

[3] Univ Ferrara, ICSI, I-44100 Ferrara, Italy

来源：

CELL CYCLE | 2008年 / 7卷 / 03期

关键词：

calcium homeostasis; apoptosis; ROS; cell death; Pin1; PKC;

D O I：

10.4161/cc.7.3.5360

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The 66 KDa isoform of Shc and its signalling properties have attracted in the past years major interest in aging research. Here, we summarize p66Shc functions and outline a specific signalling route leading to mitochondrial import, that accounts for its proapoptotic activity upon oxidative stress. This model, that could explain the alterations of mitochondrial Ca2+ homeostasis observed after oxidative stress, highlights novel pharmacological targets in age-related disorders.

引用

页码：304 / 308

页数：5

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