P66Shc, oxidative stress and aging - Importing a lifespan determinant into mitochondria

被引：70
|
作者：
Pinton, Paolo [1 ,2 ,3 ]
Rizzuto, Rosario [1 ,2 ,3 ]
机构：
[1] Univ Ferrara, Sect Gen Pathol, Dept Expt & Diagnost Med, I-44100 Ferrara, Italy
[2] Univ Ferrara, ER GenTech Lab, I-44100 Ferrara, Italy
[3] Univ Ferrara, ICSI, I-44100 Ferrara, Italy
来源：
CELL CYCLE | 2008年 / 7卷 / 03期
关键词：
calcium homeostasis; apoptosis; ROS; cell death; Pin1; PKC;
D O I：
10.4161/cc.7.3.5360
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The 66 KDa isoform of Shc and its signalling properties have attracted in the past years major interest in aging research. Here, we summarize p66Shc functions and outline a specific signalling route leading to mitochondrial import, that accounts for its proapoptotic activity upon oxidative stress. This model, that could explain the alterations of mitochondrial Ca2+ homeostasis observed after oxidative stress, highlights novel pharmacological targets in age-related disorders.
引用
收藏
页码：304 / 308
页数：5
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