Titanocene(III)-catalyzed conversion of N-(epoxyalkyl)anilines into indolines

被引：0
|
作者：
Maciejewski, John P. [1 ]
Wipf, Peter [1 ]
机构：
[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA
来源：
ARKIVOC | 2011年
关键词：
Indoline; titanocene dichloride; N-(epoxyalkyl) aniline; radical addition; MEDIATED RADICAL CYCLIZATION; STRAIGHTFORWARD SYNTHESIS; ORGANIC-SYNTHESIS; ALKYL-HALIDES; EPOXIDES; CHEMISTRY; MECHANISM; SUBSTITUTION; GENERATION; CATALYST;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Densely substituted indolines and azaindolines can be obtained by the titanocene(III) chloride catalyzed reductive opening of N-(oxiran-2-ylmethyl)anilines. The reaction optimization, substrate scope, and limitations are discussed, and a mechanistic pathway for the epoxide-opening rearrangement is proposed.
引用
收藏
页码：92 / 119
页数：28
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