Highly Stable Meldrum's Acid Derivatives for Irreversible Aqueous Covalent Modification of Amines

被引：11

作者：

Davis, Garrett J. ^{[1
]}

Sofka, Holly A. ^{[1
]}

Jewett, John C. ^{[1
]}

机构：

[1] Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 07期

关键词：

D O I：

10.1021/acs.orglett.0c00597

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This work describes the development of a highly stable and pH-responsive probe for lysine modification. The scaffold has marked stability in the presence of several biological nucleophiles and across a wide pH range (2-12). Several functional analogs showed robust labeling of a protein at pH > 9. Taken together, our system displays versatility and can be easily adapted for variety of applications, while demonstrating stability suitable for a wide range of biologically compatible systems.

引用

页码：2626 / 2629

页数：4

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