Potent and orally bioavailable stearoyl-CoA desaturase (SCD) inhibitors for the potential treatment of obesity and diabetes

被引：0

作者：

Koltun, Dmitry ^{[1
]}

Parkhilll, Eric Q. ^{[1
]}

Vasilevich, Natalya I. ^{[2
]}

Glushkov, Andrei I. ^{[2
]}

Zilbershtein, Timur M. ^{[2
]}

Ivanov, Aleksey V. ^{[2
]}

Zautke, Nathan A. ^{[3
]}

Brunn, Sandra A. ^{[3
]}

Mollova, Nevena ^{[4
]}

Leung, Kwan ^{[4
]}

Chisholm, Jeffrey W. ^{[3
]}

Zablocki, Jeff ^{[5
]}

机构：

[1] CV Therapeut, Dept Bioorgan Chem, Palo Alto, CA 94304 USA

[2] ASINEX Ltd, Dept Chem, Moscow 123367, Russia

[3] CV Therapeut, Dept Pharmacol Sci, Palo Alto, CA 94304 USA

[4] CV Therapeut, Dept Preclin Dev, Palo Alto, CA 94304 USA

[5] CV Therapeut, Dept Med Chem, Palo Alto, CA 94304 USA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 237卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

4-MEDI

引用

页数：1

共 50 条

[31] Thia fatty acids as substrates and inhibitors of stearoyl-CoA desaturase
Hoevik, K. E.
Spydevold, O. S.
Bremer, J.
B B A - Biomembranes, 1349 (03):
[32] Novel substituted heteroaromatic compounds as inhibitors of stearoyl-CoA desaturase
Dobrzyn, Pawel
Dobrzyn, Agnieszka
EXPERT OPINION ON THERAPEUTIC PATENTS, 2010, 20 (06) : 849 - 853
[33] Tumor-Activated Benzothiazole Inhibitors of Stearoyl-CoA Desaturase
Williams, Noelle S.
Gonzales, Stephen
Naidoo, Jacinth
Rivera-Cancel, Giomar
Voruganti, Sukesh
Mallipeddi, Prema
Theodoropoulos, Panayotis C.
Geboers, Sophie
Chen, Hong
Ortiz, Francisco
Posner, Bruce
Nijhawan, Deepak
Ready, Joseph M.
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 63 (17) : 9773 - 9786
[34] Thia fatty acids as substrates and inhibitors of stearoyl-CoA desaturase
Hovik, KE
Spydevold, OS
Bremer, J
BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1997, 1349 (03): : 251 - 256
[35] Targeting Stearoyl-CoA Desaturase: A novel approach for diabetes therapy
Prabhakar, Pranav Kumar
MEDICAL HYPOTHESES, 2024, 185
[36] Species-specific expression of stearoyl-CoA desaturase (SCD) in the pilosebaceous unit
Luo, J
Ge, L
Hsuan, C
Stenn, K
Prouty, S
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2001, 117 (02) : 435 - 435
[37] Discovery of Piperazin-1-ylpyridazine-Based Potent and Selective Stearoyl-CoA Desaturase-1 Inhibitors for the Treatment of Obesity and Metabolic Syndrome
Zhang, Zaihui
Sun, Shaoyi
Kodumuru, Vishnumurthy
Hou, Duanjie
Liu, Shifeng
Chakka, Nagasree
Sviridov, Serguei
Chowdhury, Sultan
McLaren, David G.
Ratkay, Leslie G.
Khakh, Kuldip
Cheng, Xing
Gschwend, Heinz W.
Kamboj, Rajender
Fu, Jianmin
Winther, Michael D.
JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (02) : 568 - 583
[38] Inhibition of stearoyl-CoA desaturase 1 (SCD1) dissociates insulin resistance and obesity from atherosclerosis
Brown, J. Mark
Chung, Soonkyu
Alger, Heather M.
Sawyer, Janet K.
Degirolamo, Chiara
Nguyen, Tam
Zhu, Xuewei
Duong, My-Ngan
Wibley, Amanda L.
Davis, Matthew A.
Kelley, Kathryn
Wilson, Martha D.
Parks, John S.
Rudel, Lawrence L.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2008, 28 (06) : E93 - E93
[39] Stearoyl-CoA desaturase 5 (SCD5), a Δ-9 fatty acyl desaturase in search of a function
Igal, R. Ariel
Sinner, Debora, I
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2021, 1866 (01):
[40] POLYMORPHISM STEAROYL-COA DESATURASE (SCD) GENE AND ASSOCIATON WITH CHARACTERISTICS MEAT IN BALI CATTLE
Alwiyah
Nuraini, H.
Agung, P. P.
Jakaria
JOURNAL OF THE INDONESIAN TROPICAL ANIMAL AGRICULTURE, 2016, 41 (04) : 188 - 195

← 1 2 3 4 5 →