An ultrasensitive electrochemical DNA sensor based on the ssDNA-assisted cascade of hybridization reaction

被引：50
|
作者：
Yin, Bin-Cheng [1 ]
Guan, Yi-Meng [1 ]
Ye, Bang-Ce [1 ]
机构：
[1] E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Lab Biosyst & Microanal, Shanghai 200237, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 35期
关键词：
ROLLING CIRCLE AMPLIFICATION; SEQUENCE-SPECIFIC DETECTION; COMPLEX MATRICES; FEMTOMOLAR DNA; APTAMER; BIOSENSOR; TARGETS; PROBES; ATP; NANOPARTICLES;
D O I：
10.1039/c2cc30997a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We have developed a simple and ultrasensitive E-DNA sensor based on the ssDNA-assisted cascade of a hybridization reaction mechanism to form a long concatamers structure to improve its sensitivity, significantly. The proposed sensor was applied to sequence-specific DNA and ATP detection. Experimental results showed a quantitative measurement with the detection limit as low as 1 aM for specific DNA and 10 fM for ATP.
引用
收藏
页码：4208 / 4210
页数：3
相关论文
共 50 条
  • [31] An ultrasensitive electrochemical immunoassay based on a proximity hybridization-triggered three-layer cascade signal amplification strategy
    Xiong, Erhu
    Jiang, Ling
    ANALYST, 2019, 144 (02) : 634 - 640
  • [32] DNA hybridization chain reaction and DNA supersandwich self-assembly for ultrasensitive detection
    Nannan Liu
    Fujian Huang
    Xiaoding Lou
    Fan Xia
    Science China(Chemistry), 2017, (03) : 311 - 318
  • [33] DNA hybridization chain reaction and DNA supersandwich self-assembly for ultrasensitive detection
    Nannan Liu
    Fujian Huang
    Xiaoding Lou
    Fan Xia
    Science China(Chemistry), 2017, 60 (03) : 311 - 318
  • [34] DNA hybridization chain reaction and DNA supersandwich self-assembly for ultrasensitive detection
    Liu, Nannan
    Huang, Fujian
    Lou, Xiaoding
    Xia, Fan
    SCIENCE CHINA-CHEMISTRY, 2017, 60 (03) : 311 - 318
  • [35] Ultrasensitive enzyme-free electrochemical immunosensor based on hybridization chain reaction triggered double strand DNA@Au nanoparticle tag
    Ge, Yanqiu
    Wu, Jie
    Ju, Huangxian
    Wu, Shuo
    TALANTA, 2014, 120 : 218 - 223
  • [36] DNA hybridization chain reaction and DNA supersandwich self-assembly for ultrasensitive detection
    Nannan Liu
    Fujian Huang
    Xiaoding Lou
    Fan Xia
    Science China Chemistry, 2017, 60 : 311 - 318
  • [37] A cascade autocatalytic strand displacement amplification and hybridization chain reaction event for label-free and ultrasensitive electrochemical nucleic acid biosensing
    Chen, Zhiqiang
    Liu, Ying
    Xin, Chen
    Zhao, Jikuan
    Liu, Shufeng
    BIOSENSORS & BIOELECTRONICS, 2018, 113 : 1 - 8
  • [38] Ultrasensitive and selective signal-on electrochemical DNA detection via exonuclease III catalysis and hybridization chain reaction amplification
    Ren, Wang
    Gao, Zhong Feng
    Li, Nian Bing
    Luo, Hong Qun
    BIOSENSORS & BIOELECTRONICS, 2015, 63 : 153 - 158
  • [39] Ultrasensitive photoacoustic sensor based on quantum cascade laser spectroscopy
    Kumar, Deepak
    Gautam, Surya
    Kumar, Subodh
    Gupta, Saurabh
    Srivastava, Hari B.
    Thakur, Surya N.
    Sharma, Ramesh C.
    SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2017, 176 : 47 - 51
  • [40] Suspended CNT-Based FET sensor for ultrasensitive and label-free detection of DNA hybridization
    Sun, Yang
    Peng, Zhisheng
    Li, Huamin
    Wang, Ziqun
    Mu, Yanqi
    Zhang, Guangping
    Chen, Shuo
    Liu, Siyu
    Wang, Gongtang
    Liu, Chundong
    Sun, Lianfeng
    Man, Baoyuan
    Yang, Cheng
    BIOSENSORS & BIOELECTRONICS, 2019, 137 : 255 - 262
12345