What does the corpus callosum tell us about brain changes in the elderly?

被引：0
|
作者：
Di Paola, Margherita [1 ,2 ]
Caltagirone, Carlo [1 ,3 ]
Spalletta, Gianfranco [1 ]
机构：
[1] IRCCS Santa Lucia Fdn, I-00179 Rome, Italy
[2] Univ Aquila, Dept Internal Med & Publ Hlth, I-67010 Laquila, Italy
[3] Univ Rome, Dept Neurosci & Memory Clin, I-00133 Rome, Italy
来源：
EXPERT REVIEW OF NEUROTHERAPEUTICS | 2011年 / 11卷 / 11期
关键词：
age-related white matter changes; corpus callosum; demyelination process; diffusion tensor imaging; elderly; region of interest; Wallerian degeneration; ALZHEIMERS-DISEASE; ATROPHY; DEGENERATION; IMPAIRMENT; MRI;
D O I：
10.1586/ERN.11.130
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The corpus callosum is the largest hemispheric interconnection bundle in the human brain. Its anterior-posterior fiber caliber gradient can help in understanding the pathophysiological mechanisms underlying white matter changes both in old age and dementia. Here, the Leukoaraiosis and Disability (LADIS) study, a longitudinal cohort study, which shows an association between corpus callosum atrophy and cognitive and motor decline in the elderly, provides the possibility to consider the use of multimodal macro-microstructural imaging of corpus callosum as a marker of structural brain changes of physiological and pathological aging.
引用
收藏
页码：1557 / 1560
页数：4
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