STIM1 moonlights as an anchor for STING

被引：12
|
作者：
Wu, Jianjun [1 ]
Yan, Nan [1 ,2 ]
机构：
[1] Univ Texas Southwestern Med Ctr Dallas, Dept Immunol, Dallas, TX 75390 USA
[2] Univ Texas Southwestern Med Ctr Dallas, Dept Microbiol, Dallas, TX 75390 USA
来源：
NATURE IMMUNOLOGY | 2019年 / 20卷 / 02期
关键词：
TRAFFICKING; ACTIVATION; ER;
D O I：
10.1038/s41590-018-0300-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Activation of STING requires its translocation from the endoplasmic reticulum (ER) through the Golgi to vesicles, but the mechanisms that control its localization have been unclear. The ER calcium sensor STIM1 acts as an ER-retention factor that anchors STING on the ER and limits STING signaling.
引用
收藏
页码：112 / 114
页数：3
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