FOXA transcription factors determine the amplitude of glucocorticoid induction of tyrosine aminotransferase in mice

被引：1
|
作者：
Bryzgalov, L. O. [1 ]
Ershov, N. I. [1 ]
Ilnitskaya, S. I. [1 ]
机构：
[1] Russian Acad Sci, Siberian Div, Inst Cytol & Genet, Novosibirsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2007年 / 144卷 / 05期
基金：
俄罗斯基础研究基金会;
关键词：
FOXA transcription factors; aminoazo dyes; tyrosine aminotransferase; glucocorticoid induction;
D O I：
10.1007/s10517-007-0415-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
o-Aminoazotoluene was more potent than 3'-methyl-4-dimethylaminoazobenzene in modulating glucocorticoid induction of tyrosine aminotransferase and DNA-binding activity of FOXA (HNF3) in 12-day-old ICR mice. In adult animals, induction of tyrosine aminotransferase and FOXA activity were modulated by o-aminoazotoluene, while 3'-methyl-4-dimethylaminoazobenzene was ineffective. Our results suggest that FOXA proteins determine glucocorticoid induction of tyrosine aminotransferase in mice (similarly to rats).
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页码：722 / 724
页数：3
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