New abietane diterpenoids from the mangrove Avicennia marina

被引:32
|
作者
Han, Li [1 ,2 ]
Huang, Xueshi [2 ]
Dahse, Hans-Martin [2 ]
Moellmann, Ute [2 ]
Grabley, Susanne [2 ]
Lin, Wenhan [1 ]
Sattler, Isabel [2 ]
机构
[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
[2] Hans Knoell Inst, Leibniz Inst Nat Prod Res & Infect Biol, D-07745 Jena, Germany
关键词
Avicennia marina; Acanthaceae; abietane diterpenoids; lignans;
D O I
10.1055/s-2008-1034318
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Phytochemical investigations of the twigs of Avicennia marina yielded three new abietane diterpenoids 11-hydroxy-8,11,13-abietatriene 12-O-beta-xylopyranoside (1), and a pair of inseparable epimers 6H alpha-11,12,16-trihydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial 11,6-hemiacetal (2) and 6H beta-11,12,16-trihydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial 11,6-hemiacetal (3), as well as the new lignan (7'S*,8'R*)-4,4',9'-trihydroxy-3,3',5,5'-tetramethoxy-7,8-dehydro-9-al-2,7'-cyclolignan (5), together with 6,11,12,16-tetrahydroxy-5,8,11, 13-abitetetraen-7-one (4), lyoniresinol (6), lyoniresinol 9'-O-beta-D-glucopyranoside (7), and diacetylmartynoside (8). Structure elucidation of the new compounds was accomplished by analysis of their spectroscopic data. Compounds 2-4 showed moderate cytotoxic and antimicrobial activities.
引用
收藏
页码:432 / 437
页数:6
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