4,6-Disubustituted quinazolines as MEK5 inhibitors

被引：0
|
作者：
Flaherty, Patrick [1 ]
Patel, Saloni [1 ]
Bhatt, Akshita [1 ]
Wright, Thomas [1 ]
Cavanaugh, Jane [1 ]
Burow, Matthew [2 ]
机构：
[1] Duquesne Univ, Pittsburgh, PA 15219 USA
[2] Tulane Univ, New Orleans, LA 70118 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 258卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
11-MEDI
引用
收藏
页数：1
相关论文
共 50 条
  • [21] ISOLATION OF MEK5 AND DIFFERENTIAL EXPRESSION OF ALTERNATIVELY SPLICED FORMS
    ENGLISH, JM
    VANDERBILT, CA
    XU, SC
    MARCUS, S
    COBB, MH
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (48) : 28897 - 28902
  • [22] Pathophysiological Impact of the MEK5/ERK5 Pathway in Oxidative Stress
    Tusa, Ignazia
    Menconi, Alessio
    Tubita, Alessandro
    Rovida, Elisabetta
    CELLS, 2023, 12 (08)
  • [23] Analysis of aryl substitution and intramolecular ligand H-bonding in selective inhibitors of the MEK5/ERK5 cascade
    Flaherty, Patrick T.
    Cavanaugh, Jane C.
    Gupta, Mohit
    Vechery, Colin
    Chakrabarty, Suravi
    Monlish, Darlene
    Wright, Thomas
    CANCER RESEARCH, 2015, 75
  • [24] Novel thiophene analogs as potential MEK5/ERK5 inhibitor
    Gupta, Mohit
    Flaherty, Patrick
    Bhatt, Akshita
    Wright, Thomas
    Cavanaugh, Jane
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [25] Design and synthesis of 4,6-substituted-(diaphenylamino)quinazolines as potent EGFR inhibitors with antitumor activity
    Li, Huan-Qiu
    Li, Dong-Dong
    Lu, Xiang
    Xu, Yun-Yun
    Zhu, Hai-Liang
    BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (01) : 317 - 323
  • [26] N-arylated 2-amino fused thiophene analogs as potential MEK5/ERK5 pathway inhibitors
    Gupta, Mohit
    Flaherty, Patrick
    Wright, Thomas
    Cavanaugh, Jane
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [27] Selective allosteric inhibition of MEK5: novel target for cancer therapeutics
    Gupta, Mohit
    Shah, Dhruv
    Flaherty, Patrick
    Wright, Thomas
    Bhatt, Akshita
    Cavanaugh, Jane
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 256
  • [28] Dual role of MEK1/2 and MEK5 in the reversal of epithelial-to-mesenchymal transition
    Hoang, Van T.
    Elliott, Steven
    Martin, Elizabeth C.
    Rhodes, Lyndsay V.
    Segar, Henry C.
    Burks, Hope
    Chakrabarty, Suravi
    Monlish, Darlene
    Phamduy, Theresa B.
    Chrisey, Doug
    Cavanaugh, Jane E.
    Flaherty, Patrick
    Collins-Burow, Bridgette M.
    Burow, Matthew E.
    CANCER RESEARCH, 2014, 74 (19)
  • [29] Expression of MAP kinase kinase-5 (MEK5) in human prostate cancer
    Jenkins, BL
    Mehta, PB
    Robson, CN
    Neal, DE
    Leung, HY
    BRITISH JOURNAL OF CANCER, 2001, 85 : 22 - 22
  • [30] Targeted Avenues for Cancer Treatment: The MEK5?ERK5 Signaling Pathway
    Pereira, Diane M.
    Rodrigues, Cecilia M. P.
    TRENDS IN MOLECULAR MEDICINE, 2020, 26 (04) : 394 - 407
12345