The enantioselective diethylzinc addition to imines catalyzed by chiral Cu(II)-oxazoline complexes

被引：25
|
作者：
Li, X [1 ]
Cun, LF [1 ]
Gong, LZ [1 ]
Mi, AQ [1 ]
Jiang, YZ [1 ]
机构：
[1] Chinese Acad Sci, Chengdu Inst Organ Chem, Key Lab Asymmetr Synth & Chirotechnol Sichuan Pr, Chengdu 610041, Peoples R China
来源：
TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 24期
关键词：
D O I：
10.1016/j.tetasy.2003.09.036
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of copper complexes of chiral bisoxazolines has been applied in the catalytic diethylzinc addition to N-sulfonyl imines. It has been found that the tridentate ligands 3-5 provided higher enantio selectivity than bidentate ones. Addition of 4 A molecular sieves to the reaction system benefits the enantioselectivity. The optimal procedure for diethylzinc addition to different imines resulted in moderate yields and enantioselectivities of up to 82% ee. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3819 / 3821
页数：3
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