Determination of furosemide in plasma and urine by gas chromatography mass spectrometry

被引：0
|
作者：
Ptacek, P
Vyhnalek, O
Breuel, HP
Macek, J
机构：
[1] PHARMACON RES,D-10623 BERLIN,GERMANY
[2] TRANQUILLITAS LABS,PRAGUE,CZECH REPUBLIC
来源：
ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1996年 / 46卷 / 03期
关键词：
CAS; 54-31-9; furosemide; determination in plasma and urine;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new method for the determination of furosemide (GAS 54-31-9) in plasma and urine by gas chromatography/mass spectrometry (GC/MS) has been developed. After acidification the samples were extracted by ethyl acetate and methylated by methyl iodide. The chromatography was carried out on a fused-silica capillary column with SE 54 stationary phase. Detection was performed by selected ion monitoring (ions 81 and 372 were monitored for furosemide and ions 363 and 406 for internal standard bumetanide). Limit of quantitation was 10 ng/ml for plasma and 40 ng/ml for urine and the calibration curves were linear up to 100,000 ng/ml.
引用
收藏
页码：277 / 283
页数：7
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