Highly efficient direct large-scale stoichiometric aldol reactions catalyzed by a new diamine salt in the presence of water

被引：4

作者：

Huang, Jing ^{[1
]}

Chen, Guodong ^{[1
]}

Fu, Xiangkai ^{[1
]}

Li, Chao ^{[1
]}

Wu, Chuanlong ^{[1
]}

Miao, Qiang ^{[1
]}

机构：

[1] Southwest Univ, Key Lab Appl Chem Chongqing Municipal, Key Lab Ecoenvironm Three Gorges Reservoir Reg, Coll Chem & Chem Engn,Res Inst Appl Chem,Minist E, Chongqing 400715, Peoples R China

来源：

CATALYSIS SCIENCE & TECHNOLOGY | 2012年 / 2卷 / 03期

关键词：

ORGANIC-REACTIONS; L-PROLINAMIDE; BIFUNCTIONAL ORGANOCATALYSTS; AMINE ORGANOCATALYSTS; N-PROLYLSULFONAMIDE; CYCLIC-KETONES; ACID; DERIVATIVES; MICHAEL; DESIGN;

D O I：

10.1039/c1cy00318f

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A new type of primary-tertiary diamine salt prepared can be used as a catalyst for direct aldol reaction and can display high yields, diastereoselectivities (up to 99 : 1), and enantiomeric excesses (up to 98%), by using stoichiometric amounts of cyclic ketones and various aryl aldehydes in the presence of water. This new catalyst can also be efficiently applied in large-scale reactions with the enantioselectivity being maintained at the same level, which indicates the potential for applications in industry.

引用

页码：547 / 553

页数：7