Highly efficient direct large-scale stoichiometric aldol reactions catalyzed by a new diamine salt in the presence of water

被引：4
|
作者：
Huang, Jing [1 ]
Chen, Guodong [1 ]
Fu, Xiangkai [1 ]
Li, Chao [1 ]
Wu, Chuanlong [1 ]
Miao, Qiang [1 ]
机构：
[1] Southwest Univ, Key Lab Appl Chem Chongqing Municipal, Key Lab Ecoenvironm Three Gorges Reservoir Reg, Coll Chem & Chem Engn,Res Inst Appl Chem,Minist E, Chongqing 400715, Peoples R China
来源：
CATALYSIS SCIENCE & TECHNOLOGY | 2012年 / 2卷 / 03期
关键词：
ORGANIC-REACTIONS; L-PROLINAMIDE; BIFUNCTIONAL ORGANOCATALYSTS; AMINE ORGANOCATALYSTS; N-PROLYLSULFONAMIDE; CYCLIC-KETONES; ACID; DERIVATIVES; MICHAEL; DESIGN;
D O I：
10.1039/c1cy00318f
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A new type of primary-tertiary diamine salt prepared can be used as a catalyst for direct aldol reaction and can display high yields, diastereoselectivities (up to 99 : 1), and enantiomeric excesses (up to 98%), by using stoichiometric amounts of cyclic ketones and various aryl aldehydes in the presence of water. This new catalyst can also be efficiently applied in large-scale reactions with the enantioselectivity being maintained at the same level, which indicates the potential for applications in industry.
引用
收藏
页码：547 / 553
页数：7
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