Biological evaluation of glucose and deoxyglucose derivatives radiolabeled with [99mTc(CO)3(H2O)3]+ core as potential melanoma imaging agents

被引：15
|
作者：
Dapueto, Rosina [2 ,3 ]
Castelli, Romina [3 ]
Fernandez, Marcelo [3 ]
Chabalgoity, Jose A. [1 ]
Moreno, Maria [1 ]
Pablo Gambini, Juan [4 ]
Cabral, Pablo [1 ]
Porcal, Williams [2 ]
机构：
[1] Univ Republica, Fac Med, Dept Desarrollo Biotecnol, Inst Higiene, Montevideo 11600, Uruguay
[2] Univ Republica, Fac Ciencia, Fac Quim, Lab Quim Organ, Montevideo 11400, Uruguay
[3] Univ Republica, Fac Ciencia, Lab Radiofarm, Ctr Invest Nucl, Montevideo 11400, Uruguay
[4] Univ Republica, Fac Med, Hosp Clin, Ctr Med Nucl, Montevideo 11600, Uruguay
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 23期
关键词：
Glucose; 99m Technetium; Radiopharmaceutical; Melanoma; Tumor diagnostic; TC-99M;
D O I：
10.1016/j.bmcl.2011.09.106
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Glucose 9 and 2-deoxyglucose 10 were successfully synthesized and radiolabeled with [(99)mTc(CO)(3)(H2O)(3)](+) intermediate in high yield. The complexes were characterized by HPLC and its stability with histidine over time was challenged. Cell uptake and biodistribution studies in melanoma-bearing C57BL/6 mice were performed. Both compounds showed accumulation in tumor tissue with high tumor-to-muscle ratios. Thus, D-glucose- and D-2-deoxyglucose-Tc-99m complex could be considered as agents for melanoma diagnosis. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7102 / 7106
页数：5
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