Retamycin production by immobilized cells of Streptomyces olindensis ICB20 in repeated-batch cultures

被引：5

作者：

Pinheiro, Iara Reboucas ^{[1
]}

Reginato Facciotti, Maria Candida ^{[1
]}

机构：

[1] Univ Sao Paulo, Escola Politecn, Dept Chem Engn, BR-05424970 Sao Paulo, Brazil

来源：

PROCESS BIOCHEMISTRY | 2008年 / 43卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

Streptomyces olindensis; immobilized cells; retamycin; repeated-batch; basket-type tank reactor; bubble column reactor;

D O I：

10.1016/j.procbio.2008.02.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Repeated-batch cultures of Ca-alginate immobilized cells of Streptomyces olindensis ICB20 for retamycin production were carried out in two different bioreactors: a basket-type stirred tank reactor (BSTR) and a bubble column reactor (BCR). Higher average values of retamycin content (R) and productivity (P-R) were achieved in the BSTR cultures (about 1.7 AU and 0.031 AU h(-1), respectively) compared to those obtained in the BCR cultures (about 0.6 AU and 0.012 AU h(-1), respectively). The BCR, on the other hand, presented significantly better operation stability than the BSTR, which makes the former much more promising regarding future industrial applications. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：661 / 666

页数：6

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