Real-life experiences with bulevirtide for the treatment of hepatitis delta-48 weeks data from a German centre

被引：15
|
作者：
Zoellner, Caroline [1 ,2 ]
Hofmann, Joerg [3 ]
Lutz, Katrin [1 ,2 ]
Tacke, Frank [1 ,2 ]
Demir, Muenevver [1 ,2 ]
机构：
[1] Charite Univ Med Berlin, Dept Hepatol & Gastroenterol, Campus Virchow Klinikum CVK, Augustenburger Pl 1, D-13353 Berlin, Germany
[2] Campus Charite Mitte CCM,Augustenburger Pl 1, D-13353 Berlin, Germany
[3] Charite Univ Med Berlin, Inst Virol, Campus Charite Mitte, Berlin, Germany
来源：
LIVER INTERNATIONAL | 2022年 / 42卷 / 11期
关键词：
entry inhibitor; HDV therapy; real-life; VIRUS;
D O I：
10.1111/liv.15408
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
In July 2020, the entry inhibitor bulevirtide was approved in the European Union for the treatment of chronic hepatitis delta virus (HDV) infection. We describe the first 48 weeks of bulevirtide therapy in eight patients (n = 7 male, n = 1 female; n = 3 compensated cirrhosis) treated at our centre. Median ALT values declined from 82 to 34 U/L after 48 weeks. Median HDV RNA dropped from 13 380 000 to 3135 copies/ml. One patient showed no significant response and was discontinued at week 16. Overall, we observed a favourable safety profile and a marked biochemical and virological response in the majority of our patients.
引用
收藏
页码：2403 / 2407
页数：5
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