Consequences of Abrupt Cessation of Alpha1-Antitrypsin Replacement Therapy

被引：28

作者：

McElvaney, Oliver J. ^{[1
]}

Carroll, Tomas P. ^{[1
]}

Franciosi, Alessandro N. ^{[1
]}

Sweeney, James ^{[1
]}

Hobbs, Brian D. ^{[2
]}

机构：

[1] Royal Coll Surgeons Ireland, Dublin, Ireland

[2] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2020年 / 382卷 / 15期

关键词：

SEVERE ALPHA-1-ANTITRYPSIN DEFICIENCY;

D O I：

10.1056/NEJMc1915484

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In Ireland, augmentation treatment of patients with genetic alpha(1)-antitrypsin deficiency was abruptly discontinued when government-industry price negotiations failed. After treatment was stopped, the incidence of hospitalization for COPD and mortality exceeded those observed while treatment was ongoing.

引用

页码：1478 / 1480

页数：3

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