Consequences of Abrupt Cessation of Alpha1-Antitrypsin Replacement Therapy

被引：28

作者：

McElvaney, Oliver J. ^{[1
]}

Carroll, Tomas P. ^{[1
]}

Franciosi, Alessandro N. ^{[1
]}

Sweeney, James ^{[1
]}

Hobbs, Brian D. ^{[2
]}

机构：

[1] Royal Coll Surgeons Ireland, Dublin, Ireland

[2] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2020年 / 382卷 / 15期

关键词：

SEVERE ALPHA-1-ANTITRYPSIN DEFICIENCY;

D O I：

10.1056/NEJMc1915484

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In Ireland, augmentation treatment of patients with genetic alpha(1)-antitrypsin deficiency was abruptly discontinued when government-industry price negotiations failed. After treatment was stopped, the incidence of hospitalization for COPD and mortality exceeded those observed while treatment was ongoing.

引用

页码：1478 / 1480

页数：3

共 50 条

[1] REPLACEMENT THERAPY OF EMPHYSEMA ASSOCIATED WITH ALPHA1-ANTITRYPSIN DEFICIENCY
VIDAL, R
MIRAVITLLES, M
DEGRACIA, X
GALLEGO, B
MORELL, F
MEDICINA CLINICA, 1991, 96 (05): : 180 - 182
[2] Clinical and Biochemical Consequences of Abrupt Cessation of Augmentation Therapy for Severe Alpha-1 Antitrypsin Deficiency
McElvaney, O. J.
Carroll, T. P.
Franciosi, A. N.
Sweeney, J.
Kowlessar, V.
Kelly, G.
Molloy, M.
O'Connor, C.
Reeves, E. P.
McElvaney, N. G.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201
[3] Alpha1-antitrypsin replacement therapy controls fibromyalgia symptoms in 2 patients with PI ZZ alpha1-antitrypsin deficiency
Blanco, I
Canto, H
de Serres, FJ
Fernandez-Bustillo, E
Rodríguez, MC
JOURNAL OF RHEUMATOLOGY, 2004, 31 (10) : 2082 - 2085
[4] LIVER REPLACEMENT FOR ALPHA1-ANTITRYPSIN DEFICIENCY
PUTNAM, CW
PORTER, KA
PETERS, RL
ASHCAVAI, M
REDEKER, AG
STARZL, TE
SURGERY, 1977, 81 (03) : 258 - 261
[5] ALPHA1-ANTITRYPSIN DEFICIENCY - VARIANT WITH NO DETECTABLE ALPHA1-ANTITRYPSIN
TALAMO, RC
LANGLEY, CE
REED, CE
MAKINO, S
PEDIATRIC RESEARCH, 1973, 7 (04) : 343 - 343
[6] ALPHA1-ANTITRYPSIN DEFICIENCY - VARIANT WITH NO DETECTABLE ALPHA1-ANTITRYPSIN
TALAMO, RC
LANGLEY, CE
REED, CE
MAKINO, S
SCIENCE, 1973, 181 (4094) : 70 - 71
[7] Patient acceptability of alpha1-antitrypsin therapy
Klein, Raymond
CHEST, 2006, 130 (04) : 183S - 183S
[8] ALPHA1-ANTITRYPSIN DEFICIENCY - REESTABLISHMENT OF THE ANTINEUTROPHIL ELASTASE PROTECTION BY INTERMITTENT PARENTERAL ALPHA1-ANTITRYPSIN THERAPY
WEWERS, M
CASOLARO, A
STRAUS, S
SELLERS, S
MCPHAUL, K
SWAYZE, S
CRYSTAL, R
CLINICAL RESEARCH, 1985, 33 (02): : A582 - A582
[9] ISOLATION OF ALPHA1-ANTITRYPSIN FROM LIVER IN ALPHA1-ANTITRYPSIN DEFICIENCY
ERIKSSON, S
LARSSON, C
DIGESTION, 1974, 10 (4-5) : 347 - 347
[10] ALPHA1-ANTITRYPSIN DEFICIENCY
LIEBERMAN, J
MEDICAL CLINICS OF NORTH AMERICA, 1973, 57 (03) : 691 - 706

← 1 2 3 4 5 →