Controllable polymerization of N-carboxy anhydrides in a microreaction system

被引：92
|
作者：
Honda, T
Miyazaki, M
Nakamura, H
Maeda, H
机构：
[1] Natl Inst Adv Ind Sci & Technol, Nanotechnol Res Inst, Saga 8410052, Japan
[2] Kyushu Univ, Interdisciplinary Grad Sch Engn Sci, Dept Mol & Mat Sci, Fukuoka 8168580, Japan
来源：
LAB ON A CHIP | 2005年 / 5卷 / 08期
关键词：
D O I：
10.1039/b505137a
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We have developed a microfluidic system for polymerization of amino acid N-carboxyanhydride and compared the properties of the products with those obtained by batchwise system under various experimental conditions. It was found that the microreactor produced polymers with narrower molecular weight distribution compared with polymers obtained by the batchwise system. Also, the molecular mass of the polymer produced using the microreactor was simply governed by the flow ( pumping) rate. These results indicated that the microreactor could be a model for synthesis of amino acid polymer with highly controllable average molecular weight and molecular weight distribution.
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页码：812 / 818
页数：7
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