Move or Die: the Fate of the Tax Oncoprotein of HTLV-1

被引：20
|
作者：
Lodewick, Julie [1 ]
Lamsoul, Isabelle [2 ,3 ]
Bex, Francoise [1 ]
机构：
[1] Univ Libre Bruxelles, Inst Rech Microbiol JM Wiame, B-1070 Brussels, Belgium
[2] CNRS, Inst Pharmacol & Biol Struct, F-31077 Toulouse, France
[3] Univ Toulouse 3, Inst Pharmacol & Biol Struct, F-31400 Toulouse, France
来源：
VIRUSES-BASEL | 2011年 / 3卷 / 06期
关键词：
HTLV-1; Tax; retrovirus; signal transduction; NF-kappa B; nuclear bodies; intracellular trafficking; posttranslational modifications; leukemia; VIRUS TYPE-1 TAX; NF-KAPPA-B; T-LYMPHOTROPIC-VIRUS; CREB BINDING-PROTEIN; DNA-DAMAGE RESPONSE; I TAX; NUCLEAR EXPORT; IKK-GAMMA; TRANSACTIVATOR TAX; KINASE IKK;
D O I：
10.3390/v3060829
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The HTLV-1 Tax protein both activates viral replication and is involved in HTLV-1-mediated transformation of T lymphocytes. The transforming properties of Tax include altering the expression of select cellular genes via activation of cellular pathways and perturbation of both cell cycle control mechanisms and apoptotic signals. The recent discovery that Tax undergoes a hierarchical sequence of posttranslational modifications that control its intracellular localization provides provocative insights into the mechanisms regulating Tax transcriptional and transforming activities.
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页码：829 / 857
页数：29
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