STUDIES ON THE ALKYLATION OF QUINOLIN-2(1H)-ONE DERIVATIVES

被引：3
|
作者：
Chen, Chia-Ling [1 ]
Chen, I-Li [2 ]
Chen, Jih-Jung [2 ]
Wei, Dau-Chang [2 ]
Hsieh, Han-Jie [2 ]
Chang, Ken-Ming [3 ]
Tzeng, Cherng-Chyi [3 ]
Wang, Tai-Chi [2 ]
机构：
[1] KUO Gen Hosp, Dept Pharm, Tainan 700, Taiwan
[2] Tajen Univ, Dept Pharm, Pingtung 907, Taiwan
[3] Kaohsiung Med Univ, Coll Life Sci, Dept Med & Appl Chem, Kaohsiung 807, Taiwan
来源：
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY | 2015年 / 60卷 / 01期
关键词：
N-Alkylation; O-Alkylation; Quinolin-2(1H)-one; METHYLIDENE-GAMMA-BUTYROLACTONES; N-ALKYLATION; O-ALKYLATION; 2-PYRIDONE; INHIBITORS; AGENTS; CATALYSIS;
D O I：
10.4067/S0717-97072015000100008
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Alkylation of quinolin-2(1H)-one (1) and its C(6) and C(7) substituted dervatives (OMe, OBn, and Cl) with 2-bromoacetophenone or chloroacetone under basic condition (K2CO3 in DMF) gave a mixture of N-1-and O-2-alkylated products with the former one as a major product. However, alkylation of 8-methoxy-, 8-benzyloxy-, and 8-chloro-quinolin-2(1H)-ones under the same reaction conditions gave exclusively O-2-alkylated products.
引用
收藏
页码：2812 / 2816
页数：5
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