Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial

Aims/hypothesisExercise is recommended for the treatment and prevention of type 2 diabetes. However, the most effective time of day to achieve beneficial effects on health remains unknown. We aimed to determine whether exercise training at two distinct times of day would have differing effects on 24h blood glucose levels in men with type 2 diabetes.MethodsEleven men with type 2 diabetes underwent a randomised crossover trial. Inclusion criteria were 45-68years of age and BMI between 23 and 33kg/m(2). Exclusion criteria were insulin treatment and presence of another systemic illness. Researchers were not blinded to the group assignment. The trial involved 2weeks of either morning or afternoon high-intensity interval training (HIIT) (three sessions/week), followed by a 2week wash-out period and a subsequent period of the opposite training regimen. Continuous glucose monitor (CGM)-based data were obtained.ResultsMorning HIIT increased CGM-based glucose concentration (6.90.4mmol/l; mean +/- SEM for the exercise days during week 1) compared with either the pre-training period (6.4 +/- 0.3mmol/l) or afternoon HIIT (6.2 +/- 0.3mmol/l for the exercise days during week 1). Conversely, afternoon HIIT reduced the CGM-based glucose concentration compared with either the pre-training period or morning HIIT. Afternoon HIIT was associated with elevated thyroid-stimulating hormone (TSH; 1.9 +/- 0.2mU/l) and reduced T-4 (15.8 +/- 0.7pmol/l) concentrations compared with pre-training (1.4 +/- 0.2mU/l for TSH; 16.8 +/- 0.6pmol/l for T-4). TSH was also elevated after morning HIIT (1.7 +/- 0.2mU/l), whereas T-4 concentrations were unaltered.Conclusions/interpretation Afternoon HIIT was more efficacious than morning HIIT at improving blood glucose in men with type 2 diabetes. Strikingly, morning HIIT had an acute, deleterious effect, increasing blood glucose. However, studies of longer training regimens are warranted to establish the persistence of this adverse effect. Our data highlight the importance of optimising the timing of exercise when prescribing it as treatment for type 2 diabetes.