A structural biology perspective on bioactive small molecules and their plant targets

被引：19

作者：

Kumari, Selva ^{[1
]}

van der Hoorn, Renier A. L. ^{[1
]}

机构：

[1] Max Planck Inst Plant Breeding Res, Plant Chemet Lab, Chem Genom Ctr, Max Planck Soc, D-50829 Cologne, Germany

来源：

CURRENT OPINION IN PLANT BIOLOGY | 2011年 / 14卷 / 05期

关键词：

ACETYL-COENZYME; CARBOXYLTRANSFERASE DOMAIN; CRYSTAL-STRUCTURE; CYTOKININ OXIDASE/DEHYDROGENASE; SULFONYLUREA HERBICIDES; INHIBITING HERBICIDES; METHYL SALICYLATE; AUXIN PERCEPTION; MECHANISM; CARBOXYLASE;

D O I：

10.1016/j.pbi.2011.06.003

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Structural biology efforts in recent years have generated numerous co-crystal structures of bioactive small molecules interacting with their plant targets. These studies include the targets of various phytohormones, pathogen-derived effectors, herbicides and other bioactive compounds. Here we discuss that this collection of structures contains excellent examples of nine collective observations: molecular glues, allostery, inhibitors, molecular mimicry, promiscuous binding sites, unexpected electron densities, natural selection at atomic resolution, and applications in structure-guided mutagenesis and small molecule design.

引用

页码：480 / 488

页数：9

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