Effect of IFN-α on CC14-induced fibrosis of the liver and immune status in mice of different age

被引：1

作者：

Filimonov, PN ^{[1
]}

Sukhenko, TG

Gavrilova, NI

Shkurupii, VA

机构：

[1] Novosibirsk State Med Acad, Novosibirsk, Russia

[2] Russian Acad Med Sci, Inst Clin Immunol, Siberian Div, Novosibirsk, Russia

[3] Russian Acad Med Sci, Res Ctr Clin & Expt Med, Siberian Div, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2005年 / 139卷 / 03期

关键词：

CCl4; fibrosis; age; IFN-alpha;

D O I：

10.1007/s10517-005-0284-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In young, adult, and old mice fibrosis was induced by administration of CCl4 and treated with IFN-alpha. Liver fibrosis was evaluated by morphometry of argyrophilic fibers, immune status by the splenocyte proliferative response. Minimum immunosuppression and maximum antifibrotic effect were observed in young mice, while adult mice exhibited pronounced immunotoxicity and weak response to interferon therapy.

引用

页码：324 / 327

页数：4

共 50 条

[41] The effect of immune status, age and genetic background on induction of oral tolerance to Actinomyces viscosus in mice
Sosroseno, Wihaskoro
Herminajeng, Endang
Bird, Phil
BIOMEDICINE & PHARMACOTHERAPY, 2015, 70 : 294 - 298
[42] IFN-α-2b treatment protects against diet-induced obesity and alleviates nonalcoholic fatty liver disease in mice
Quiroga, Ariel D.
Comanzo, Carla G.
Heit Barbini, Francisco J.
Lucci, Alvaro
Vera, Marina C.
Lorenzetti, Florencia
Ferretti, Anabela C.
Ceballos, Maria P.
Alvarez, Maria De L.
Carrillo, Maria C.
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 379
[43] THE EFFECT OF DIFFERENT LEVELS OF EXCESS DIETARY VITAMIN-A (RETINYL PALMITATE) ON IMMUNE STATUS IN MICE
MULHERN, SA
MITCHELL, GV
FASEB JOURNAL, 1988, 2 (05): : A1113 - A1113
[44] Effect of Lutein on Ocular Goblet Cell, IFN-γ, and IL-17 Concentration in Dry Eye-Induced Mice Model
Faustine, Giovani
Prijanti, Ani R.
Wibowo, Heri
CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (07)
[45] Hepatoprotective effect and possible mechanism of phytoestrogen calycosin on carbon tetrachloride–induced liver fibrosis in mice
Mengmeng Zhang
Yaxin Wang
Guannan Zhu
Cheng Sun
Jiajia Wang
Naunyn-Schmiedeberg's Archives of Pharmacology, 2021, 394 : 189 - 204
[46] OM85 ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting Notch expression and modulating the IFN-γ/IL-4 ratio
Yu, Yaling
Li, Zhuanyun
Hu, Zhenghao
Peng, Tianfeng
Niu, Ruijie
Sun, Peng
Wang, Xiaorong
Zhang, Jinnong
SCIENTIFIC REPORTS, 2025, 15 (01):
[47] Protective effect of recombinant interferon (IFN)-alpha/beta on MHV-2cc-induced chronic hepatitis in athymic nude mice
Uetsuka, K
Nakayama, H
Goto, N
EXPERIMENTAL ANIMALS, 1996, 45 (03) : 293 - 297
[48] Liver-specific HBsAg transgenic mice are over-sensitive to Poly(I:C)-induced liver injury in NK cell- and IFN-γ-dependent manner
Chen, Yongyan
Sun, Rui
Jiang, Wei
Wei, Haiming
Tian, Zhigang
JOURNAL OF HEPATOLOGY, 2007, 47 (02) : 183 - 190
[49] The effect of hydroalcoholic extract of Nigella sativa on infected mice with Plasmodium berghei: evaluation of immune deviation and the serum level of IFN-γ and IL-4
Tappeh, K. Hazrati
Seyedy, S.
Ghaderi, M.
Mikaili, P.
TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2015, 20 : 187 - 187
[50] Inhibitory Effect of Antisense Oligonucleotide Targeting TIMP-2 on Immune-Induced Liver Fibrosis
Qing-He Nie
Chuan-Long Zhu
Ya-Fei Zhang
Jie Yang
Jiu-Cong Zhang
Ren-Tao Gao
Digestive Diseases and Sciences, 2010, 55 : 1286 - 1295

← 1 2 3 4 5 →