In vitro reactivation of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing methoxy ether linkages

被引：21
|
作者：
Acharya, Jyotiranjan [1 ]
Gupta, Arvind Kumar [1 ]
Mazumder, Avik [1 ]
Dubey, Devendra Kumar [1 ]
机构：
[1] Def Res & Dev Estab, Proc Technol Dev Div, Jhansi Rd, Gwalior 474002, India
来源：
TOXICOLOGY IN VITRO | 2008年 / 22卷 / 02期
关键词：
bis-pyridinium oximes; reactivators; 2-PAM; sarin; nerve agents; acetylcholinesterase; obidoxime;
D O I：
10.1016/j.tiv.2007.10.006
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Bis-pyridinium oximes connected by methoxy alkane ether linker were synthesized and their in vitro reactivation efficacy was evaluated for sarin inhibited ACNE. Reactivation efficacy of synthesized compounds was compared with 2-PAM and obidoxime. Among the synthesized compounds, 1,2-dimethoxy ethylene bis-[3,3'-(hydroxyiminomethyl) pyridinium] dichloride (3P-2) and 1,3-dimethoxy propylene bis-[3,3'-(hydroxyiminomethyl) pyridinium] dichloride (3P-3) were found to be most potent reactivators for AChE inhibited by nerve agent sarin. 3P-2 and 3P-3, respectively exhibited 80% and 69% regeneration of inhibited ACNE, whereas 2-PAM (well known antidote for nerve agent poisoning) showed 42% regeneration. (C) 2007 Elsevier Ltd. All rights reserved.
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页码：525 / 530
页数：6
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