In vitro reactivation of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing methoxy ether linkages

被引：21

作者：

Acharya, Jyotiranjan ^{[1
]}

Gupta, Arvind Kumar ^{[1
]}

Mazumder, Avik ^{[1
]}

Dubey, Devendra Kumar ^{[1
]}

机构：

[1] Def Res & Dev Estab, Proc Technol Dev Div, Jhansi Rd, Gwalior 474002, India

来源：

TOXICOLOGY IN VITRO | 2008年 / 22卷 / 02期

关键词：

bis-pyridinium oximes; reactivators; 2-PAM; sarin; nerve agents; acetylcholinesterase; obidoxime;

D O I：

10.1016/j.tiv.2007.10.006

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Bis-pyridinium oximes connected by methoxy alkane ether linker were synthesized and their in vitro reactivation efficacy was evaluated for sarin inhibited ACNE. Reactivation efficacy of synthesized compounds was compared with 2-PAM and obidoxime. Among the synthesized compounds, 1,2-dimethoxy ethylene bis-[3,3'-(hydroxyiminomethyl) pyridinium] dichloride (3P-2) and 1,3-dimethoxy propylene bis-[3,3'-(hydroxyiminomethyl) pyridinium] dichloride (3P-3) were found to be most potent reactivators for AChE inhibited by nerve agent sarin. 3P-2 and 3P-3, respectively exhibited 80% and 69% regeneration of inhibited ACNE, whereas 2-PAM (well known antidote for nerve agent poisoning) showed 42% regeneration. (C) 2007 Elsevier Ltd. All rights reserved.

引用

下载

页码：525 / 530

页数：6

共 22 条

[1] In-vitro regeneration of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing xylene linker
Acharya, Jyotiranjan
Gupta, Arvind Kumar
Mazumder, Avik
Dubey, Devendra Kumar
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (03) : 1326 - 1330
[2] In vitro reactivation potency of novel symmetrical bis-pyridinium oximes for electric eel acetylcholinesterase inhibited by nerve agent sarin
Acharya, Jyotiranjan
Dubey, Devendra Kumar
Kaushik, M. P.
TOXICOLOGY IN VITRO, 2011, 25 (08) : 2135 - 2139
[3] In vitro evaluation of bis-pyridinium oximes bearing methoxy alkane linker as reactivators of sarin inhibited human acetylcholinesterase
Acharya, Jyotiranjan
Dubey, Devendra Kumar
Raza, Syed Kalbey
TOXICOLOGY IN VITRO, 2010, 24 (06) : 1797 - 1802
[4] In vitro reactivation of sarin-inhibited human acetylcholinesterase (AChE) by bis-pyridinium oximes connected by xylene linkers
Acharya, Jyotiranjan
Dubey, Devendra Kumar
Srivastava, Ashish Kumar
Raza, Syed Kalbey
TOXICOLOGY IN VITRO, 2011, 25 (01) : 251 - 256
[5] In vitro reactivation of organophosphorus (OP)-inhibited electric eel acetylcholinesterase by novel monoquaternary pyridinium oximes
Jyotiranjan Acharya
Hemlata Rana
V. Aditya Kapil
M. P. Kaushik
Medicinal Chemistry Research, 2013, 22 : 1277 - 1286
[6] In vitro reactivation of organophosphorus (OP)-inhibited electric eel acetylcholinesterase by novel monoquaternary pyridinium oximes
Acharya, Jyotiranjan
Rana, Hemlata
Kapil, V. Aditya
Kaushik, M. P.
MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (03) : 1277 - 1286
[7] In vitro reactivation kinetics of paraoxon- and DFP-inhibited electric eel AChE using mono- and bis-pyridinium oximes
Gupta, Bhanushree
Sharma, Rahul
Singh, Namrata
Kuca, Kamil
Acharya, J. R.
Ghosh, Kallol K.
ARCHIVES OF TOXICOLOGY, 2014, 88 (02) : 381 - 390
[8] In vitro reactivation kinetics of paraoxon- and DFP-inhibited electric eel AChE using mono- and bis-pyridinium oximes
Bhanushree Gupta
Rahul Sharma
Namrata Singh
Kamil Kuca
J. R. Acharya
Kallol K. Ghosh
Archives of Toxicology, 2014, 88 : 381 - 390
[9] REACTIVATION OF SARIN-PHOSPHONYLATED OR SOMAN-PHOSPHONYLATED HUMAN ACETYLCHOLINESTERASE BY BIS-PYRIDINIUM MONO-OXIMES
SUN, MC
LI, FZ
CHOU, TC
BIOCHEMICAL PHARMACOLOGY, 1986, 35 (02) : 347 - 349
[10] Synthesis and evaluation of novel bis-pyridinium oximes as reactivators of DFP-inhibited acetylcholinesterase
Acharya, Jyotiranjan
Gupta, Arvind Kumar
Dubey, Devendra Kumar
Raza, Syed Kalbey
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (03) : 1335 - 1340

← 1 2 3 →