Strongylophorines, meroditerpenoids from the marine sponge Petrosia corticata, function as proteasome inhibitors

被引：24

作者：

Noda, Ai ^{[1
]}

Sakai, Eriko ^{[1
]}

Kato, Hikaru ^{[1
]}

Losung, Fitje ^{[2
]}

Mangindaan, Remy E. P. ^{[2
]}

de Voogd, Nicole J. ^{[3
]}

Yokosawa, Hideyoshi ^{[4
]}

Tsukamoto, Sachiko ^{[1
]}

机构：

[1] Kumamoto Univ, Grad Sch Pharmaceut Sci, Dept Nat Med, Kumamoto 8620973, Japan

[2] Sam Ratulangi Univ, Fac Fisheries & Marine Sci, Manado 95115, Indonesia

[3] Nat Biodivers Ctr, NL-2300 RA Leiden, Netherlands

[4] Aichi Gakuin Univ, Sch Pharm, Chikusa Ku, Nagoya, Aichi 4648650, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2015年 / 25卷 / 13期

关键词：

Strongylophorine; Meroditerpenoid; Petrosia corticata; Proteasome inhibitor; ACANTHOSTRONGYLOPHORA-INGENS; DRUG TARGETS; DURISSIMA; CANCER; SYSTEM;

D O I：

10.1016/j.bmcl.2015.04.075

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new strongylophorine derivatives, along with six known strongylophorines, were isolated from the marine sponge Petrosia corticata as proteasome inhibitors. Of these, a hemiacetal mixture of strongylophorines-13/-14 was the strongest inhibitor of the proteasome with an IC50 of 2.1 mu M. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：2650 / 2653

页数：4

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