Akt/mammalian target of rapamycin signaling pathway regulates neurite outgrowth in cerebellar granule neurons stimulated by methylcobalamin

被引：38
|
作者：
Okada, Kiyoshi [1 ,2 ]
Tanaka, Hiroyuki [3 ]
Temporin, Ko [4 ]
Okamoto, Michio [1 ]
Kuroda, Yusuke [1 ]
Moritomo, Hisao [1 ]
Murase, Tsuyoshi [1 ]
Yoshikawa, Hideki [1 ]
机构：
[1] Osaka Univ, Grad Sch Med, Dept Orthopaed, Suita, Osaka 5650871, Japan
[2] Osaka Univ Hosp, Med Ctr Translat Res, Suita, Osaka 5650871, Japan
[3] Osaka Koseinenkin Hosp, Dept Orthopaed Surg, Osaka 5530003, Japan
[4] Toyonaka City Hosp, Dept Orthopaed Surg, Toyonaka, Osaka 5608566, Japan
来源：
NEUROSCIENCE LETTERS | 2011年 / 495卷 / 03期
关键词：
Akt; Mammalian target or rapamycin; Methylcobalamin; Neurite outgrowth; PROMOTES NERVE REGENERATION; HIGH-DOSE METHYLCOBALAMIN; MAMMALIAN TARGET; DNA METHYLATION; SCIATIC-NERVE; AKT; MTOR; KINASE; GROWTH; RAF;
D O I：
10.1016/j.neulet.2011.03.065
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Methylcobalamin (MeCbl), a vitamin B12 analog, promotes neurite outgrowth by activating Akt in neurons. However, Akt is involved in many cellular functions, and the downstream signal of Akt that promotes neurite outgrowth in neurons in the presence of MeCbl remains obscure. Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase that regulates multiple cellular functions including neurite outgrowth. mTOR is regarded as important for the regeneration of injured nerves. In this study, we examined the relationship between MeCbl and mTOR activity and found that MeCbl increases mTOR activity via the activation of Akt and promotes neurite outgrowth in cerebellar granule neurons via the activation of mTOR. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：201 / 204
页数：4
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