Synthesis of 5-(4-bromophenyl)- and 5-(5-bromothiophen-2-yl)-substituted 3-aryl[1,2,4]triazolo[4,3-c]quinazolines

被引：6

作者：

Nosova, E., V ^{[1
,2
]}

Kopotilova, A. E. ^{[1
]}

Ivan'kina, M. A. ^{[1
]}

Moshkina, T. N. ^{[1
]}

Kopchuk, D. S. ^{[1
,2
]}

机构：

[1] Ural Fed Univ, 19 Ul Mira, Ekaterinburg 620002, Russia

[2] Russian Acad Sci, I Ya Postovskii Inst Organ Synth, Ural Branch, 20 Ul S Kovalevskoi, Ekaterinburg 620219, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2022年 / 71卷 / 07期

关键词：

1; 2; 4]triazolo[4; 3-c]quinazolines; oxidative cyclization; 2-(4-bromophenyl)quinazolin-4-one; 4-hydrazinoquinazolines; hydrazones; SAR;

D O I：

10.1007/s11172-022-3554-7

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of [1,2,4]triazolo[4,3-c]quinazolines, bearing 3-positioned p-bromophenyl or 5-bromothiophen-2-yl fragment, was synthesized by oxidative cyclization of the corresponding hydrazones with bromine in glacial acetic acid at room temperature. The obtained tricyclic derivatives are valuable intermediates for biologically active compounds and fluorophores.

引用

页码：1483 / 1487

页数：5

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