Iron oxide-based superparamagnetic polymeric nanomaterials: Design, preparation, and biomedical application

被引：350

作者：

Oh, Jung Kwon ^{[1
]}

Park, Jong Myung ^{[2
]}

机构：

[1] Concordia Univ, Dept Chem & Biochem, Montreal, PQ H4B 1R6, Canada

[2] Pohang Univ Sci & Technol, Grad Inst Ferrous Technol, Surface Engn Lab, Pohang 790784, South Korea

来源：

PROGRESS IN POLYMER SCIENCE | 2011年 / 36卷 / 01期

关键词：

SIONPs; Magnetic nanoparticles; Biomedical applications; MRI; Drug delivery; Hyperthermia; Polymer-SIONP nanomaterials; TRANSFER RADICAL POLYMERIZATION; BIOFUNCTIONAL MAGNETIC NANOPARTICLES; FRAGMENTATION CHAIN TRANSFER; IN-SITU SYNTHESIS; ONE-POT REACTION; DRUG-DELIVERY; HYBRID NANOPARTICLES; MRI CONTRAST; NANOCOMPOSITE MICROSPHERES; DISPERSION POLYMERIZATION;

D O I：

10.1016/j.progpolymsci.2010.08.005

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Recent advances in the development and biological applications of polymeric nanomaterials embedded with superparamagnetic iron oxide nanoparticles (SIONPs) are summarized. Novel SIONP-polymer hybrid nanoparticles are prepared by various methods, including direct modification with polymers, surface-initiated controlled polymerization, inorganic silica/polymer hybridization, self-assembly, self-association, and various heterogeneous polymerization methods. They have potential for various biomedical applications, including magnetic resonance imaging (MRI) contrast enhancement, targeted drug delivery, hyperthermia, biological separation, protein immobilization, and biosensors. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：168 / 189

页数：22

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